EXPERTISE:
TOXICOLOGICAL AND ECOTOXICOLOGICAL

Our expert ecotoxicologists and toxicologists support you in the evaluation of substances and products, and the implementation of REACH, CLP and Biocidal products (BPR) regulations.

EXPERTISE IN TOXICOLOGY AND ECOTOXICOLOGY FOR WHAT EXPECTATIONS?

With a team of doctors of science and pharmacy specializing in toxicology and ecotoxicology, ATOUT CHIMIE's consultants support you through the realization of personalized expertise tailored to your expectations.

Our knowledge of the properties and dangers of substances as well as our experience of regulatory processes and the assessment methods of the authorities related to REACH, CLP and the regulation of biocidal products (BPR) allow us to meet regulatory obligations, but also to anticipate changes. Thus, our expertise will allow you to secure your product portfolios and future developments.

PRESENTATION OF THE TYPES OF EXPERTISE PROPOSED

EXPERTISE IN TOXICOLOGY, ECOTOXICOLOGY IN ALL REGULATORY FIELDS

• Monitoring and monitoring of laboratory studies: validation of protocols, analytical developments, critical review of results and deviations, validation of study reports

• Hazard assessment, strategy for generating missing data (data gap considering possible extrapolations or "read-across" and "waivings") through experimentation or QSAR

• Expology, computer modeling (ConsExpo, ART, ECETOC TRA, EUSES, ...)

• Risk assessment

• Modeling of skin absorption

• Identification of endocrine disruptors (screening, in-depth studies)

• Identification of nanomaterials, toxicological profile and risk assessment

• Cocktail effects assessment, risk assessment of chemical mixtures

• Identification of degradation by-products, trace pollutants and metabolites in the environment

EXPERTISE IN THE CONTEXT OF REACH IMPLEMENTATION

• Screening of hazardous properties of substances
• Identification of substances of SVHC concern (and likely to be subject to authorization) or likely to become so
• Identification of persistent, bioaccumulative and toxic substances (PBT, vPvB)
• Chemical Safety Report (CSR) for the registrant and downstream user (DU CSR)

EXPERTISE IN THE CONTEXT OF THE IMPLEMENTATION OF CLP

• Consolidation of the classification of substances and mixtures
• Comparison of the dangerousness of products, scoring grid (internal request, support for a call for tenders, etc.)

EXPERTISE IN THE FRAMEWORK OF THE IMPLEMENTATION OF THE BIOCIDAL PRODUCTS REGULATIONS (BPR)

• Risk assessment with a view to a file or upstream of a product development
• Expology: modeling and identification of an existing scenario (Emission Scenario Document (ESD) from ECHA)
• Identification of cumulative exposure data
• Drafting of the risk assessment report in ECHA's "Product Assessment Report" (PAR) format
• Risk assessment strategy for a single product or a family

TOXICOLOGICAL AND ECOTOXICOLOGICAL PROFILES

• Cosmetic ingredients

• Plant-based food supplements

• Plant extracts, complex natural substances

• Substances used in the composition of children's toys

• Food contact materials

• Detergents

• Medicines (active ingredients and excipients)

• Medical devices

• Etc